Mechanism of Action of Amniotic ECM Treatment

Dr. Jose A. Rivera, DPM, FABFAS

Director, Foot & Ankle Services at OrthoRegenX

While traditional amniotic products don’t have live stem cells, they do have two interesting things going for them. First, they may have unique cytokines and growth factors that may help tissue healing.  Second, and likely more important, is that they are likely an all-purpose ECM.

It has been demonstrated that various ECM products help change the environment for healing. Basically, they are able to take local macrophages (the cells that help repair by taking out the garbage) to go from an M1 state (pro-inflammation and breakdown) to an M2 state (pro-growth and repair). So the efficacy of amnion may be more about its ability to shift a chronic injury site from scarring, swelling, and poor repair to lower inflammation and repair.

Our Personic Health providers have the ability to offer patients a variety of Regenerative treatment options. For more information, contact us at (855) 479-4217.

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Amniotic products have been used successfully for over a century in the setting of problematic tissue healing and have enjoyed a stellar safety record. Following recent clinical success with treating orthopedic injuries, there has been renewed interest in the treatments for musculoskeletal disease and injury. An abundance of scientific and clinical evidence has demonstrated the